Bryce Love rushed for 136 yards and a touchdown and K.J. Costello threw for 183 yards and a touchdown and Stanford opened its Pac-12 Conference football season with a 17-3 victory over USC on Saturday.
Malik Antoine intercepted two passes, one in the end zone, late in the game to seal the victory.
Jet Toner tacked on a 30-yard field goal late in the third quarter, giving the Cardinal (2-0, 1-0) plenty of breathing room to run out the clock.
Love broke one of his patented runs, a 59-yarder that led to Toner's field goal. He nearly broke another one in the fourth quarter.
"Can't commend Bryce Love enough," Stanford coach David Shaw said. "His patience, his toughness, breaking tackles, getting two yards when there was two yards there, getting two yards sometimes when two yards weren't there and then the big runs happen. We know that about him."
Stanford opened the game with an 8-play, 83-yard drive that culminated in Love's six-yard touchdown run.
The Cardinal defense held USC to 20 yards on its first possession and played well throughout, limiting the Trojans to a field goal a week after they torched UNLV for 43 points.
Bobby Okereke and Sean Barton each recorded 10 tackles for Stanford, which hosts UC Davis in a nonleague game next Saturday at 11 a.m.
The Aggies beat San Jose State in week one and pounded San Diego, 54-21, Saturday.
Bartin, Casey Toohill, Joey Alfieri and Jordan Fox were each in on a combined four quarterback sacks.
Senior strong safety Ben Edwards added nine tackles and broke up one pass.
"I really felt the momentum in terms of when I came off the field on a third down that we didn't pick up, I really had trust that I was going to be out there pretty quickly and that's a great feeling," Costello said.
Stanford went into halftime with a 14-0 lead after Costello and Colby Parkinson connected on a nine-yard scoring toss with 34 seconds left in the second quarter.
"We knew we were making it hard on ourselves there that first half," Costello said. "At times we came out with a good first drive and then from there we continuously shot ourselves in the foot. But third down, we converted some of those, we always want to be playing in front of the stick."
Costello was 16 of 27 passing and did not throw an interception.
Trent Irwin caught five passes for 31 yards and Kaden Smith and JJ Arcega-Whiteside each caught four passes for 77 and 62 yards, respectively.