Senior Focus | November 1, 2013 | Palo Alto Weekly | Palo Alto Online |

Palo Alto Weekly

- November 1, 2013

Senior Focus

EXERCISE AND COGNITION ... Neurologist Thomas Rando a professor at Stanford School of Medicine and deputy director of Stanford's Center on Longevity, is co-recipient of a $4.26 million "transformative research" award from the National Institutes of Health to encourage high-risk, high-reward approaches to biomedical and behavioral research. Along with neurologist Tony Wyss-Coray, professor of medicine and senior research career scientist at the Veterans Affairs Palo Alto Health Care System, Rando will explore the basis for physical activity's robust positive effect on cognitive function. Aging is associated with progressive decline in cognitive ability. Muscle is increasingly understood to be a secretory tissue with effects on bone structure, metabolism and blood vessel formation. Rando and Wyss-Coray will test the idea that factors produced in exercised muscle are secreted into the circulation, where they gain access to the brain and induce cognitive benefits. They will identify the neural cells whose behavior is modified by those secreted factors and that mediate the effects those factors induce during exercise and afterward.

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Items for Senior Focus may be emailed to Palo Alto Weekly Staff Writer Chris Kenrick at


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