Stanford University researchers have received a $2 million, four-year federal grant to design stem cells to repair damage caused by heart attacks.

Stem cells can be used to become a variety of other cells, including heart cells. The new research project will be determine how to add muscle stimulation to stem cells so they can fully function as heart cells once they are implanted.

"We want to guide researchers in what kind of stimuli are important," said Beth Pruitt, a mechanical engineering assistant professor who heads the project funded by the National Science Foundation.

"We are developing bioreactors that allow us to vary those conditions and to produce coordinated beating tissues that are aligned and appear functional."

The goal is allow such cells to improve cardiovascular functions after a heart attack, she said.

Other members of the research team are: Sarah Heilshorn, materials science and engineering assistant professor; Ellen Kuhl, mechanical engineering assistant professor; Joseph Wu, radiology and medicine assistant professor, and Christopher Zarins, professor of surgery.

-- Don Kazak